SORT1 with oncogenic potential associated hypomethylation and promotes tumor progression in hepatocellular carcinoma

Background: Hepatocellular carcinoma (HCC) is the one of most common cancers and lethal diseases in world. SORT1 a neuronal type-1 membrane protein member Vps10p-domain receptor family, which was abundantly expressed cells. However, effect on HCC progression remains unclear hepatocellular carcinoma. Material methods: Analysis various public omics datasets revealed that overexpressed HCC. Next, we performed enrichment SORT1-related genes TCGA network analysis protein-protein interactions. When examining regulatory mechanism SORT1, observed negative correlation between methylation status mRNA expression TCGA_LIHC dataset. The cg16988986 CpG island 5′ promoter region hypomethylated compared to matched non-tumor samples. Results: In this study, first identified significantly HCCs tissues clinically related with prognosis Cancer Genome Atlas liver project (TCGA_LIHC) dataset GSE114564 knockdown suppressed cell growth proliferation cells, reduced metastatic potential We targeted inactivation cycle proteins caused apoptotic death Also, found inverse DNA gene SORT1. Although downregulated according tumor stage, upregulated. Conclusions: suggest might be candidates for therapeutic target No conflict interest.